Abstract Heart shape captures variation in cardiac structure beyond traditional phenotypes of mass and volume.Although observational studies have demonstrated associations with cardiometabolic risk factors and diseases, its genetic basis Retaining Pin is less understood.We utilised cardiovascular magnetic resonance images from 45,683 UK Biobank par
Emperor Penguin Optimizer (EPO) is a recently developed population-based meta-heuristic algorithm that simulates the huddling behavior of emperor penguins.Mixed results have been observed on the performance of EPO in solving general optimization problems.Within the EPO, two parameters need to be tuned (namely ${f}$ and ${l}$ ) to ensure a good bala
Xiangyu Zhang,1,* Zelai He,2,* Longquan Xiang,1 Liang Li,1 Haiyan Zhang,1 Fanzhong Lin,1 Hongying Cao11Department of Pathology, Jining First People’s Hospital, Jining Medical University, Jining 272000, People’s Republic of China; 2Department of Radiation Oncology, The First Affiliated Hospital of Bengbu Medical University & Tumor Ho
The stabilization of G-Quadruplex DNA structures by ligands is a promising strategy for telomerase inhibition in cancer therapy since this enzyme is responsible for the unlimited proliferation of cancer cells.To assess the potential of a compound as a telomerase inhibitor, selectivity for quadruplex over duplex DNA is a fundamental attribute, as th